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SEMA was shown to be the most effective of its category in terms of meaningful weight reduction as it can penetrate certain areas in the central nervous system that are critical for hunger and appetite control and are not protected by the blood-brain barrier, regulating key appetite-modulating relay areas [70, 73]
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With respect to the SOUL trial, oral semaglutide demonstrated a 14% reduction in MACE outcomes, independent of concurrent SGLT2 inhibitor use
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