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When GLP-1 was administered to Glp1r −/− mice fed ad libitum 30 min before ghrelin, GLP-1 did not affect ghrelin-induced feeding (Fig
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Whether the clinical efficacy of GLP-1 medicines in these conditions is primarily mediated by weight loss or by additional mechanisms such as improved insulin sensitivity, restoration of metabolic control and reduced inflammation remains an open question (Figure 1B), since most large clinical trials are not designed to elucidate the underlying molecular mechanism
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