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Zone 1: Safe refrigeration (36-46°F) Optimal storage No time limit (until expiration date on unopened product, or 21-28 days after first use) Zero expected degradation Zone 2: Controlled room temperature (47-86°F) Safe for Zepbound pens after first use, up to 21 cumulative days Not safe for compounded tirzepatide at any point Minimal degradation if time limit is respected Zone 3: Elevated temperature (87-104°F) Unsafe for all tirzepatide products Discard if exposure exceeds 4 hours Common in summer car storage, luggage left in sun, or near heating vents Zone 4: Extreme temperature (below 32°F or above 104°F) Immediate discard required Freezing causes ice crystal formation, which ruptures peptide structure Extreme heat causes rapid hydrolysis [Diagram suggestion: thermometer graphic with four color-coded zones, each labeled with temperature range, time limits, and "safe" vs

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You might reference published trials or ongoing research, including their limitations