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Nausea/aversion The concern with nausea resulting from GLP-1 should not come as a surprise as this is in fact the most common side effect reported in patients receiving GLP-1 analog treatment (Calara et al., 1997, 1998
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Unless there are contraindications or adverse drug reactions, dual-combination therapy should first be initiated with metformin, and if the glycemic target is still not achieved, triple-combination therapy should be initiated by adding agents with different mechanisms of action [497-499]
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