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Can GLP-1's Be Used to Treat Lupus in Patients with Diabetes?
GLP-1R activation engages intracellular signaling cascades via Gs proteins, AC, PKA, and EPAC, leading to increased insulin secretion and maintenance of β-cell function: it enhances β-cell proliferation and survival, reduces apoptosis and senescence, improves glucose sensitivity, decreases fatty acid oxidation and gluconeogenesis, and promotes energy expenditure (Figure 2) [44,45,46]
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