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The article says metformin requires caution in advanced kidney disease at an eGFR below 30, active liver disease, and acute illness or contrast procedures, and is not recommended in pregnancy

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4.2 GLP-1-based agents The focus of GLP-1RA development has predominantly been on designing GLP-1 derivatives resistant to DPP-4 enzymatic activity and exhibiting slow renal clearance through chemical modification and pharmaceutical formulation