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When investigators applied the treatment policy estimand, individuals administered semaglutide achieved superior weight loss of 15.1% compared to a reduction of 2.4% with the placebo and 84.9% achieved a weight loss of 5% or more compared to the placebo at 25.8%
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Vomiting Diarrhea Constipation Indigestion Decreased appetite Less Common but Serious Side Effects: Hypoglycemia (low blood sugar) : Especially when used in combination with other diabetes medications like insulin
