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The SUSTAIN clinical trial program included Phase IIIA RCTs (SUSTAIN 1–5) to assess the effectiveness and safety of weekly subcutaneous semaglutide in a diverse group of T2DM patients, ranging from drug-naïve to those on oral antidiabetics and/or insulin [39–43]

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Key unanswered legal and operational questions include how bridge costs will be financed, effects on patient out-of-pocket limits, and overlap with forthcoming negotiated prices under the Medicare Drug Price Negotiation Program