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Three rules cover roughly 80% of muscle preservation on GLP-1 drugs: eat 1.6 to 2.0 grams of protein per kilogram of bodyweight per day, lift heavy 2 to 3 times per week, and keep weekly weight loss under about 1% of bodyweight

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GLP-1 receptor agonists also reduced the risk of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, and all-cause mortality, with high-certainty evidence