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With TZP treatment, insulin sensitivity rises by 65.7%, measured by the glucose infusion rate indispensable to maintain euglycemia, and the rise was 20.5% greater with TZP than with semaglutide 37.5% with semaglutide 1 mg)

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Beyond traditional GLP-1RAs, dual and emerging multi-agonists may have additional metabolic and renal implications