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In the 72-week SURMOUNT-1 clinical trial (the phase-3 trial that led to FDA approval), people taking 5 mg of tirzepatide lost an average of 15.0% of their body weight, compared with 19.5% for those taking 10 mg and 20.9% for those taking 15 mg
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The sample sizes ranged widely, from as few as 98 participants in the study by Buse et al
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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