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Possible neuroendocrine regulation of GLP-1 secretion is supported by studies in rodents in which nutrient flow to the distal intestine is prevented, precluding direct L-cell contact in this part of the intestine to luminal nutrients, [289,320]

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“Persons with type 2 diabetes tend to also have some degree of increased body weight or obesity and we know that achieving at least 5% body weight helps to improve glucose and cardiometabolic risk factors.” MNT spoke with Jennifer Cheng, DO, chief of endocrinology at Hackensack Meridian Jersey Shore University Medical Center in New Jersey — who was not involved in this study — who commented it is important to find new options for the treatment of type 2 diabetes and give patients the choice of administering either via subcutaneous injections or just a daily pill

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