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GLP-1 receptor agonists and next-generation metabolic hormone therapies in chronic kidney disease | Nature Reviews Nephrology
Specifically, carriers of GIPR variants that are pharmacologically classified as loss-of-function variants with reduced cell surface expression, cAMP production, beta arrestin 2 recruitment, internalization, and endosomal signaling have consistently been associated with lower adiposity-related traits, including BMI (103) and nominally lower prevalence of obesity (97–99)
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4A–H), except for a significant decrease in basal glucose levels in GLP1/GIP-treated mice (Fig
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