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The most common adverse effects of Zepbound include: Nausea (24-29%, dose-dependent) Diarrhea (18-24%, dose-dependent) Vomiting (8-12%, dose-dependent) Constipation (16-17%, dose-dependent) Abdominal pain and dyspepsia Decreased appetite These gastrointestinal effects are typically most pronounced during dose initiation and escalation, often improving over time as the body adjusts to the medication
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