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In the TECOS trial treatment sitagliptin also reduced the urinary albumin to creatinine ratio with no effect on eGFR (273)
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Amphetamine vs methylphenidate: different weight-loss profiles The two major stimulant classes have different pharmacological profiles that translate to different weight-loss patterns: Amphetamines (Adderall, Vyvanse, Dexedrine): Mechanism: block dopamine reuptake AND trigger active dopamine release from neurons Peak appetite suppression: 2 to 4 hours after dose Duration: 6 to 14 hours depending on formulation Weight loss: 7 to 12 pounds average over 12 months Tolerance development: slower, partial Rebound hunger: moderate to severe when medication wears off Methylphenidates (Ritalin, Concerta, Focalin): Mechanism: block dopamine reuptake only Peak appetite suppression: 1 to 3 hours after dose Duration: 3 to 12 hours depending on formulation Weight loss: 3 to 7 pounds average over 12 months Tolerance development: faster, more complete Rebound hunger: mild to moderate The practical difference: patients on amphetamines report more consistent appetite suppression throughout the day
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