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Rybelsus (semaglutide) is a GLP-1 receptor agonist that does not cause physical dependence or withdrawal symptoms when stopped abruptly Discontinuing Rybelsus leads to rising blood glucose levels, increased appetite, and potential weight regain as the medication's effects diminish over 4–5 weeks Stopping without medical supervision and an alternative diabetes management plan increases risk of poor glycaemic control and long-term complications NICE and MHRA guidance recommend discussing any medication changes with your healthcare team to ensure continuity of diabetes management Safe discontinuation requires monitoring blood glucose levels, implementing lifestyle strategies, and potentially starting alternative medications under medical supervision Table of Contents What Happens When You Stop Taking Rybelsus Suddenly Rybelsus (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist used to improve glycaemic control in adults with type 2 diabetes mellitus