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Through the interaction of these receptors, the brain can receive signals of peripheral inflammation and respond through neural signaling, thereby modulating or alleviating the inflammatory response

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In favour of a clinically relevant role of GLP-1 in reducing systemic inflammation, a meta-analysis of randomised clinical trials concluded that GLP-1 receptor agonists reduce circulating levels of inflammatory biomarkers, including C-reactive protein and tumour necrosis factor (TNF)-α [12]