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If you've missed two or more consecutive doses , the UK product information provides two options: You may resume at your current dose, or Your clinician may consider reinitiating the dose-escalation schedule to reduce gastrointestinal side effects If restarting with the dose-escalation schedule, this typically follows: Weeks 1โ4 : 0.25 mg once weekly Weeks 5โ8 : 0.5 mg once weekly Weeks 9โ12 : 1 mg once weekly Weeks 13โ16 : 1.7 mg once weekly Week 17 onwards : 2.4 mg once weekly (maintenance dose) If you don't tolerate a dose increase, your clinician may delay it by 4 weeks