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Combination therapy reduced HF exacerbations (HR 0.62, 95% CI 0.58-0.67), all-cause mortality (HR 0.64, 95% CI 0.54-0.75), and hospitalizations (HR 0.74, 95% CI 0.71-0.78), alongside lower risks of atrial fibrillation, pulmonary hypertension, and renal injury
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Opportunities and challenges of clinical research in the big-data era: From RCT to BCT
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