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In high-income nations with established diabetes care systems, GLP-1 receptor agonists exhibit advantageous cost-effectiveness ratios when accounting for cardiovascular and renal protective benefits, with incremental cost-effectiveness ratios generally falling below $50,000 per quality-adjusted life year (QALY) for high-risk patients (Kong et al
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These agents include thiazolidinediones (PPAR-γ agonists), dipeptidyl peptidase-4 (DPP-4) inhibitors, sulfonylureas, sodium-glucose co-transporter 2 (SGLT2) inhibitors, α-glucosidase inhibitors, and glucagon-like peptide-1 (GLP-1) receptor agonists
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