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Rapid decreases can affect the hypothalamic-pituitary-ovarian axis [12] [13] Changes in body fat percentage : Particularly relevant when body fat drops below certain thresholds Caloric restriction effects : Even with adequate nutrition, significant energy deficits can temporarily suppress reproductive function Metabolic adaptation : The body may prioritise essential functions over reproduction during periods of rapid metabolic change For women taking GLP-1 medications , the weight loss achieved may be more rapid than with lifestyle changes alone, potentially increasing the likelihood of temporary menstrual disruption

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The dual amylin- and calcitonin-receptor agonist KBP-042 works as adjunct to metformin on fasting hyperglycemia and HbA1c in a rat model of type 2 diabetes