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However, HFD-feeding has been shown to induce alpha-cell hyperplasia prior to the expansion of beta-cell mass in mice (100), and similarly, studies performed in normoglycemic non-human primates demonstrate that alpha-cell mass was more significantly augmented in response to the increased duration and severity of obesity than that of beta-cells (101)
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Indian J Nephrol 2019;29:278–281 [DOI] [PMC free article] [PubMed] [Google Scholar] 309
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