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Furthermore, the GLP-1/GLP-1R axis controls high-fat diet (HFD)-induced altered microbiota-associated chronic inflammation, including hypothalamus inflammation, by maintaining enhanced leptin sensitivity along with maintaining colonocyte homoeostasis and metabolic energy status [91,92]

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On restarting, the weight loss curve typically follows a compressed version of the original timeline, reaching previous weight within 60 to 75 percent of the original timeframe