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APE1 expression was found to be reduced by phosphatidylinositol-3 kinase (PI3K) inhibition but not by mitogen-activated protein kinase (MEK) suppression, and administration of exendin-4 (a GLP-1 analogue) was observed to enhance DNA repair in ischemic stroke rat brains [38]

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full renal and cardiovascular benefits observed by week 24 in clinical trials