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GLP-1 receptor agonists may counteract osteoarthritis that occurs in the cartilage, synovial membrane, Hoffa fat pad, and bone tissue through the interaction between the GLP-1 receptor agonists and the GLP-1 receptors expressed in joint cells, such as chondrocytes, as well as in macrophages, in adipocytes, and on the osteocyte surface ( Figure 4 )
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GLP-1 RAs and Cardiovascular and Kidney Outcomes by Body Mass Index in Type 2 Diabetes
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