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Researchers should consider whether findings are: Consistent across independent studies Supported by complementary analytical methods Observed in more than one experimental model Robust to alternative statistical approaches Biologically plausible Reported with appropriate uncertainty Limited by small samples or short observation periods Research Limitations Retatrutide research remains subject to limitations associated with model selection, sample size, study duration, protocol design, analytical methodology, missing data, and statistical assumptions

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In the phase 2 dose-escalation study (Jastreboff et al., NEJM, 2023), gastrointestinal adverse events were reported in a substantial proportion of participants, with incidence increasing at higher doses