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In conclusion, as we demonstrate here, the fusion of peptide therapeutics to an albumin-binding DARPin, if engineered properly, is a straightforward and modular protein engineering strategy to enhance the therapeutic efficacy of short-circulating biologics
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A Cleveland Clinic team led by cardiologist Amgad Mentias, MD, recently published a large database analysis showing that bariatric surgery in Medicare enrollees with obesity was associated with lower risk of mortality, new-onset heart failure and myocardial infarction ( J Am Coll Cardiol