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Ascendis Pharma GLP-1 Receptor Agonist Weight Management Diabetes Treatments
In the ATTAIN-1 Phase 3 obesity trial (NEJM, September 2025), orforglipron at 36 mg produced approximately 12.4% weight loss over 72 weeks using the efficacy estimand (~27.3 lbs), with 36.0% of participants reaching ≥15% weight loss
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