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Electrophysiological recordings support this notion and have demonstrated that GLP-1 directly stimulates POMC/CART cells, whereas GLP-1 can also inhibit orexigenic NPY/AgRP cells in the ARC through an indirect mechanism (Secher et al., 2014)

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Energy deficiency may enhance intracortical remodeling and reduce periosteal bone apposition, leading to a net loss of cortical thickness and strength