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Without amidation in the C- terminal, RhGLP-1 (7-36) is the complete amino acid sequence of GLP-1 (7-36)-NH2 and is more homologous to human as compared to other GLP-1 RAs such as exenatide ( GLP-1(9-36) NH2 is formed by the DPP-4 enzyme cleaving the N-terminal dipeptide His-Ala of GLP-1(7-36) NH2 ( Exenatide Exenatide (Byetta® and Bydureon®, AstraZeneca), originally discovered as Exendin-4 (Ex-4) in the saliva of the gila monster (Heloderma suspectum), is a synthetic peptide with 39 amino acids ( There has been evidence that intraperitoneal injection of Ex-4 protected against ischemia-induced neuronal apoptosis potentially by upregulating expression of the GLP-1R mainly in GABAergic interneurons or astrocytes in the hippocampal CA1 region of gerbils ( Another study ( Though GLP-1 RAs have been recognized to improve glucose tolerance and induce sustained secretion of insulin after discontinuing therapy, yet no study has been conducted to determine whether Ex-4 plays a continuing role in protecting against stroke after cessation of therapy and the potential mechanisms

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Novo is also launching higher-dose formulations, developing companion therapies, and pursuing additional indications (cardiovascular prevention, kidney disease)