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GLP-1 Receptor Signaling and Oral Dysfunction: A Narrative Review on the Mechanistic Basis of Semaglutide-Related Oral Adverse Effects - PMC
In the peripheral system, GLP-1R mediates the actions of GLP-1 via the incretin axis, in which stimulation of the GLP-1R with GLP-1 primarily triggers insulin release from islet β cells in a glucose-dependent manner and inhibits glucagon secretion from islet α cells (110)
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Some researchers have explored whether combining GLP-1 stimulation with DPP-4 inhibition could amplify supplement effects, and that theoretical approach has merit, but no GLP-1 supplement currently on the market takes this combined approach in a clinically validated way